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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Daphnetin, Cisplatin
Phytochemical Name Daphnetin (PubChem CID: 5280569 )
Anticancer drug Name Cisplatin (PubChem CID: 5702198 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Decreasing Drug Toxicity
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The theory of cold and heat
Drug Name Cisplatin
Adverse Reactions Myelosuppression, dry mouth and throat, fever, dry stools. This was inferred hot nature anticancer drug.
Recommendations Cold: Anemarrhena asphodeloides; Urena lobataL; Artemisia scoparia; Swertia mussotii; Swertia pseudochinensis; Gentiana manshurica; Gossampinus malabarica; Pyrrosia sheareri; Pyrrosia sheareri; Iris domestica; Gentiana scabra; Pyrrosia sheareri; Pyrrosia petiolosa
Reference ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.　　ref_link
Combination Pair ID: 344
Ref_1
Pair Name Daphnetin, Cisplatin
Disease Info Nephrotoxicity /
Gene Regulation Up-regulation Expression GABPA hsa2551
Up-regulation Expression HMOX1 hsa3162
Result The results of this study suggested that daphnetin inhibited cisplatin-induced nephrotoxicity by inhibiting NF-κB and activating Nrf2 signaling pathways. Daphnetin might be a promising agent in the treatment of kidney injury.
03. Reference
No. Title Href
1 Daphnetin protects against cisplatin-induced nephrotoxicity by inhibiting inflammatory and oxidative response. Int Immunopharmacol. 2018 Dec;65:402-407. doi: 10.1016/j.intimp.2018.10.018. Click
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